![]() ![]() Higher doses have also been known to cause haemolytic anaemia (or lower doses in those patient with G6PD deficiency). ![]() Do not exceed >7mg/kg as it will paradoxically cause methaemoglobinaemia.Once administered pulse oximetry will be unreliable. Use with caution in patients with renal failure as methylene blue is primarily excreted renally.A single dose of 1-2mg/kg has been suggested as an adjunct in toxic shock states.Paediatric dose = 1 mg/kg (for first dose). More recently, methylene blue has gained recognition for its efficacious use in the treatment of ifosfamide neurotoxicity and refractory vasoplegic shock in.MetHb levels should be measured hourly during any treatment until a consistent fall is documented. ![]() During oxidation, the iron atom loses an electron to an oxidant and is converted from the ferrous state (Fe2+) to the ferric state (Fe3+).
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